NOT KNOWN DETAILS ABOUT NAD+ AND ITS ROLE IN MITOCHONDRIAL FUNCTION

Even though originally thought to play a minimal role in mammalian NAD+ synthesis, it has been recently prompt that the de novoHeLa cells appear to be significantly dependent on the de novo pyrimidine synthesis pathway offered their bigger levels from the dihydroorotate dehydrogenase (DHODH) and UMPS enzymes. Also, pointing to distinct mechanisms o